Advances in Coronary Physiology

Allen Jeremias, MD, MSc, is the Director of Interventional Cardiology Research and Associate Director of the Cardiac Catheterization Laboratory at St. Francis Hospital in Roslyn, New York. He is also a member of the Cardiovascular Research Foundation in New York City where he currently serves as the Director of the Physiology Core Laboratory. He completed his medical training at The Cleveland Clinic Foundation, Stanford University School of Medicine, and Harvard Medical School. He has been a high volume interventional cardiologist since 2006 and recognized as a Top Doctor in the New York Metro Area by Castle Connolly. Dr. Jeremias has significantly contributed to advancing the field of interventional cardiology and he is considered one of the foremost authorities in coronary physiology and intravascular imaging. He is a co-director of the annual St. Francis Intravascular Imaging and Coronary Physiology Workshop, teaching physicians around the world on “Precision Angioplasty”. Dr. Jeremias is presently engaged in a major global study that could change the path of treating clogged arteries. Known as the ILUMIEN IV trial, this major clinical study is evaluating Optical Coherence Tomography (OCT) to guide coronary stent placement. He is also the principal investigator of DEFINE PCI, an international study on assessing the improvement in blood flow after stent placement for severe coronary blockages.

Prof Andrew Sharp qualified from Edinburgh Medical School in 1998 and is Professor of Cardiology at the University Hospital of Wales and Cardiff University in the U.K. He conducted his early training at the Royal Infirmary of Edinburgh, before moving to London for his senior clinical training. He completed the prestigious Milan-Imperial Interventional Cardiology Fellowship programme, having spent a year in San Raffaele and Columbus Hospitals, Milan, Italy, under the tutelage of Professor Antonio Colombo. He also spent three years training in interventional cardiology at Imperial College Hospitals in London. Prof Sharp was awarded an MD postgraduate research degree from the University of Edinburgh for his work on the hypertensive heart and his research interests include intracoronary imaging and physiology. as well as the use of device-based treatments for hypertension and pulmonary embolism.

Dr. Bruce Samuels is an interventional cardiologist on staff at Cedars-Sinai Medical Center (CSMC) in Los Angeles, California. Dr. Samuels completed his medical studies at Albert Einstein College of Medicine in New York before returning to Southern California to complete his residency and chief residency in Internal Medicine at Harbor-UCLA Medical Center. At CSMC, he trained in both general and interventional cardiology before joining the medical staff there. In addition to his clinical practice in coronary intervention, Dr. Samuels has actively participated in numerous interventional trials including IVUS guided therapy, coronary physiology and microvascular disease. He is also working closely with the Barbra Streisand Women’s Heart Center based at CSMC, working as an interventionalist in the active coronary reactivity research there. As co-chair of a 30-day readmissions task force, he has helped to shape policy for CSMC in its efforts to improve quality delivery of care. He has frequently been invited as faculty to many scientific meetings and is a sought after speaker for numerous peer educational platforms. Dr. Samuels is a fellow of the American College of Cardiology and is Board Certified in Internal Medicine, Cardiovascular Diseases, and Interventional Cardiology. He is married with three sons; his outside interests include contemporary art and long distance running.

Carlo Di Mario is Professor of Cardiology at the University of Florence and Director of the Structural 
Interventional Cardiology Division of the University Hospital Careggi, Florence, Italy. Previous posts included 15 years as Professor of Clinical Cardiology at Imperial College of Sciences, Medicine & Technology, London and Consultant Cardiologist at the Royal Brompton Hospital. Despite his teaching, research and administrative commitments, he maintains an active clinical involvement performing more than 100 PCI per year with special interest in the treatment of calcified lesions, chronic total occlusions, bifurcations, and diffuse disease. He is a regular TAVI operator and certified implanter for the Medtronic Evolut R and Edwards Sapien 3 transcatheter aortic valves. He participated in more than 160 MitraClip implantations in London and Florence and has recently started direct annuloplasty with the CardioBand. Professor Di Mario pioneered the use of intracoronary Doppler, pressure measurement, intravascular ultrasound, optical coherence tomography, and near infrared spectroscopy. He was PI of the OPTICUS trial, failing to demonstrate superiority of IVUS guided stenting, and of the Lipid Rich Plaque study, due to report at TCT 2018. He was Principal Investigator of the DESTINI trial, using Doppler CRF to identify lesions in need of stenting, and of the CARESS in AMI trial, a large multicentre trial showing that patients who receive fibrinolytic therapy for ST-elevation myocardial infarction benefit from early angioplasty. This trial and a subsequent meta-analysis have led to a change in the European Society of Cardiology and AHA/ACC Guidelines for treatment of STEMI patients. He cooperated with Dr Davies to the validation of iFR to assess lesion severity and discriminate the contribution of individual lesions, and with Dr Lyon in the intracoronary delivery of SERCA-2 genes via adenoviral vectors in the CUPID2 trial.

Dr Christopher Cook is a Medical Research Council Clinical Fellow at Imperial College London, undertaking a PhD in coronary physiology under the supervision of Dr Justin Davies. He studied Medicine at University College London (UCL) and graduated with Distinction (Clinical Medicine and Clinical Sciences) in his final MBBS Examinations in 2009. He achieved a First Class (Honours) Bachelor of Science degree in Physiology undertaking a period of research at The Hatter Cardiovascular Institute. He was awarded ‘The Dean’s List’ for outstanding performance in the Faculty of Life Sciences. In total he was awarded 17 prizes including the prestigious Gold Medal Medicine (proxime accessit). In 2014, he was awarded the Imperial Valve and Cardiovascular Course Young Investigator Prize. In 2015 he was awarded the inaugural EuroPCR’s Got Talent Award. In 2017 he was elected onto the EuroPCR Clinical Programme Committee.

A physician at Dudley, United Kingdom. Features in 1 video on Wondr Medical. David Mackereth generally speaks on Coronary Physiology, Instantaneous wave-Free Ratio (iFR), and Fractional Flow Reserve (FFR).

Prof. Eric Van Belle is Professor of Interventional Cardiology at the University of Lille and Head of Catheterization laboratories, Cardiology Department at the University Hospital of Lille.
He is a fellow of the French Society of Cardiology, the European Society of Cardiology and
the American College of Cardiology. A member of the European Association of Percutaneous Coronary Intervention (EAPCI) and a member of the director bureau of the French Working Group of Interventional Cardiology (GACI), he is the Director of the French Interventional Cardiology Training Program, and reviewer of multiple Medical Journals and Abstracts. His research interests include basics and clinical aspects of the outcome of high risk population such as diabetics and post-MI patients following percutaneous coronary interventions (PCI),
the use of biomarkers for risk prediction and therapeutic strati cation at the time of PCI, the role of angiogenesis and collateral circulation for endogenous cardiovascular repair and the use of gene therapy and stem cell therapy for regenerating cardiovascular function including myocardial and valve function. More recently it included also the optimization of transcatheter aortic valve intervention (TAVI), in particular the use of ore-procedural imaging and the understanding of the role post-procedural aortic regurgitation.

Dr Fausto Rigo graduated in Medicine in 1982 and specialized in Cardiovascular Diseases and in Sports Medicine at the University of Padua. From 1985 to 2011, he was a consultant Cardiologist at the Division of Cardiology of Umberto I Hospital of Mestre-Venice. Since 2011, Dr Rigo was Head of Division of Cardiology of dell’Angelo Hospital in Mestre-Venice, Italy. In 2022, Dr Fausto became Head of Center of Cardiology in Villa Salus Hospital/Santa Camillo IRCSS in Venice. He is author of co-author of over 130 papers all registered in PubMed, published and peer reviewed international journals, and over 250 original or inviter oral presentations, at the main scientific events. Impact factor > 500. Author of numerous chapters of books on Imaging in Cardiology. Field of interest: Coronary artery disease, Cardiomyopathy, Heart failure, Expert in Echocardiography/Stress Echocardiography, Magnetic Resonance and CT-Scan, and pioneer in the implementation of coronary flow and reserve assessment with ultrasound.

Prof. Flavio L. Ribichini is Full Professor of Cardiovascular Medicine and Director of the Division of Cardiovascular Medicine of the University of Verona, where he has served since 2006. Since 2022, he has been a chief of the cardio-thoracic department. Dedicated full time to Interventional Cardiology since 1993, he was Associate Professor of Cardiology and Director of the Catheterization Laboratory of the University Amedeo Avogadro in Novara, Italy from 2002 to 2006. He also worked as a full-time staff cardiologist at the Intensive Care Unit and the Catheterization Unit at Ospedale Santa Croce in Cuneo, Italy in the nineties. Prof. Ribichini obtained his medical degree in 1986 at the National University of Cordoba, Argentina, and then completed his fellowship in Internal Medicine in 1988. He obtained his board certification in Cardiology at the University of Torino, Italy in 1992. He had extensive training around the world in interventional cardiology, including at the University of Paris VII, Henry Mondor Hospital; Stanford University, California; and Mount Sinai Medical School, New York. In addition, he was a awarded a Research Fellowship of the ESC at the OLVZ Cardiovascular Centre, Aalst, Belgium. Prof. Ribichini is the Director of the School of Cardiovascular Medicine and the President of the PhD Department of the University of Verona. He is member of the Editorial Board of the European Heart Journal, member of the Executive Board of the European Association of Percutaneous Cardiovascular Interventions (EAPCI), member ESC Guidelines Task Force, and of the of the scientific committee of the Euro-PCR and the TCT. He is Coordinator, Principle Investigator, and member of the steering committees of several clinical trials and has authored over 350 full publications on clinical and basic cardiovascular research in peer reviewed scientific journals available on PubMed with an H index: 42.

A consultant cardiologist at Charite Hospital, Berlin, Germany. Features in 2 videos on Wondr Medical. Florian Krackhardt generally speaks on Instantaneous wave-Free Ratio (iFR), Fractional Flow Reserve (FFR), Coronary Physiology, and Intravascular Ultrasound (IVUS).

Guus de Waard works at Radboudumc, Nijmegen, The Netherlands.

Dr Habib Samady is an interventional cardiologist and serves as President of the Georgia Heart Institute, the heart and vascular program of Northeast Georgia Health System. He is also Director of the Georgia Center for Cardiovascular Biomechanics and Modeling and Adjunct Professor of Medicine at Emory University. Dr Samady is recognized as one of the foremost international experts in coronary physiology. He earned his medical degree from the University of Sheffield in England, and completed his residency training in both London and in Sheffield. He subsequently completed an internal medicine residency and chief residency at the University of Connecticut, before his fellowship in general cardiology, nuclear cardiology, and interventional cardiology at Yale University in Connecticut.

Works at Hospital Clinico San Carlos, Madrid, Spain. Features in 2 videos on Wondr Medical. Hernan Mejia generally speaks on Instantaneous wave-Free Ratio (iFR), Fractional Flow Reserve (FFR), Coronary Flow Reserve (CFR), Coronary Physiology, and Live Cases.

A consultant cardiologist at Hammersmith Hospital, Imperial College London, UK. Features in 33 videos on Wondr Medical. Iqbal Malik generally speaks on Live Cases, Instantaneous wave-Free Ratio (iFR), Catheter laboratory skills, Intravascular Ultrasound (IVUS), and Virtual histology (VH).

Prof Javier Escaned is Head of Section (Interventional Cardiology Section) at Hospital Clinico San Carlos / Complutense University (Madrid, Spain). He trained in the United Kingdom as Specialist in Cardiology and obtained his PhD in The Netherlands. Author of >600 indexed scientific articles on interventional cardiology, imaging and physiology (h-index 74) and over 30 years of experience as PCI operator, he regularly lectures and performs live cases at major scientific and educational meetings. He is a recipient of the European Society of Cardiology (ESC) Silver Medal and the Andreas Grüntzig Award for his contributions to the fiedl fo Interventional Cardiology. Main areas of expertise include complex PCI, intracoronary diagnostics and functional coronary angiography. His track record in coronary physiology comprises being investigator on pioneer FFR trials like DEFER (1998), collaborator with Justin Davies in the validation and clinical implementation of iFR, and developer of new tools for the assessment of coronary microcirculation. Editorial roles include Deputy Editor EHJ, Advisory Editor Eurointervention, editor of the textbooks “Coronary Stenosis: Imaging, Structure and Physiology” and “Physiological Assessment of Coronary Stenoses and the Microcirculation". Recent board positions include EAPCI board / Education Committee Chair, ESC WG Coronary Pathophysiology and Microcirculation, EuroCTO Board. Recent trials as Principal Investigator include ADVISE II, DEFINE FLAIR, SYNTAX II, PIONEER IV, Cerebral-Coronary-Connection (C3), DCR4Contrast, INOCA LongCovid and AID ANGIO. Additional interests are philosophy and music.

Works at Essex Cardiothoracic Centre, Basildon, UK. Features in 2 videos on Wondr Medical. John Davies generally speaks on Coronary Physiology, Fractional Flow Reserve (FFR), Instantaneous wave-Free Ratio (iFR), NSTEMI, and Coronary Optical Coherence Tomography (OCT).

Juliet Nilsson is a creative manager at Simple Education, UK.

Dr Justin Davies is a honorary 
interventional cardiologist at Hammersmith Hospital, Imperial College NHS Trust, London. After training at Imperial College, he won a prestigious BHF research fellowship to study arterial haemodynamics. Since then he has continued to
work on the development of mathematical algorithms to aid understanding of large artery physiology and to develop new tools to assess arterial disease. The holder of several patents,
he has published widely in the field of hypertension, coronary and large artery physiology and is the winner of many national and international awards. He has several international collaborations, and is the developer of iFR and the co-principal investigator of the ADVISE studies, the DEFINE-FLAIR, ORBITA and DEFINE-PCI studies. Justin also has an interest in renal denervation, and has lead the first-in-man studies to evaluate the safety of this technique to patients with chronic systolic heart failure (REACH studies).

Manesh Patel is the Chief of the Division of Cardiology and the Division of Clinical Pharmacology. His clinical interests include diagnostic and interventional coronary angiography, peripheral angiography and endovascular intervention. His is involved in several clinical trials involving patients with cardiovascular disease and in cardiac imaging. He is also the Chair of the American College of Cardiology Task Force for Appropriate Use Criteria for Cardiovascular Procedures and is Chair of the American Heart Association Diagnostic and Interventional Cath Committee. Patel's interest in cardiac imaging, quality of care, cardiac devices is also evident in his research. His integration of these efforts into his roles at Duke was recognized in 2010 when he received the prestigious Duke Cardiology Fellowship Mentor Award. In 2011, Dr. Patel was named the endowed John Bush Simpson Assistant Professor of Cardiology. In 2013, Dr. Patel received the Robert M. Califf Faculty clinical research Award. Currently, Dr. Patel is leading an effort to redesign the delivery of care to patients undergoing invasive catheterization procedures in the health system with a specific aim of measure and providing individualized, patient centered, innovative, and efficient care.

Dr Mauro Echavarría Pinto is an Interventional cardiologist and currently works at “ISSSTE“ General Hospital in Querétaro, México. He trained clinically in the National Institutes of Health, in Mexico City, and in Hospital Clínico San Carlos, in Madrid, Spain. He holds a MSc degree in Research Methodology, Design and Statistics in Health Sciences from the Autonomous University of Barcelona, Spain, and a PhD from the University of Amsterdam, The Netherlands. He is an author of >50 peer-reviewed manuscripts mostly focused on the use of coronary physiology to guide the treatment of ischaemic heart disease.

Works at Hammersmith Hospital, Imperial College London, UK. Features in 2 videos on Wondr Medical. Nicolas Foin generally speaks on Coronary Physiology, Coronary Flow Reserve (CFR), Computational Fluid Dynamics (CFD), Coronary Optical Coherence Tomography (OCT), and Bifurcation.

Niels van Royen is an interventional cardiologist and Head of Department of Cardiology at the Radboud University Medical Center, Nijmegen, the Netherlands. He has a background in pre-clinical research and is head of a research group on translational research in repair mechanisms in ischemic heart disease. Also he is principal investigator of several multi-center clinical trials like the TRANSIENT, COACT, REDUCE-MVI and iMODERN. These trials focus on timing of interventional procedures as well as the use of intra-coronary physiology to guide interventional procedures both in stable coronary artery disease as well as acute coronary syndromes.

Dr Nieves Gonzalo is Consultant Interventional Cardiologist at the Interventional Cardiology Department at Clinico San Carlos University Hospital in Madrid. She obtained her Specialist Certification in Cardiology after training at Clinico San Carlos University Hospital in Madrid. Subsequently, she underwent a research fellowship at Thoraxcenter, Erasmus University Rotterdam (The Netherlands) under the supervision of Professor Patrick Serruys, focused mainly in intracoronary imaging and bioabsorbable stents. In 2010 she obtained her PhD with the thesis “Optical coherence tomography for the assessment of coronary atherosclerosis and vessel response after stent implantation”. Her track record includes over 170 articles indexed in PubMed, as well as book chapters in Interventional Cardiology textbooks. Recent research projects as principal investigator includes a study about the assessment of neoatherosclerosis and its clinical impact in patients with restenosis (RIBS IV and V OCT substudy) and research regarding vessel injury and healing evaluation with different stent platforms evaluated with OCT (VISTA study). Dr Gonzalo is a dedicated educationalist with involvement in many areas of complex PCI, serving currently as Deputy Editor for Eurointervention and Committee Member of EuroPCR.

Prof Patrick W. Serruys with respected h-index – 183 is a professor of Interventional Cardiology at the Interuniversity Cardiological Institute of the Netherlands (1988-1998) and Erasmus MC. Since 1980 he was a Director of the Clinical Research Program of the Catheterization Laboratory, Thorax Center at Erasmus University, and till April 1, 2014 (retirement date) the Head of the Interventional Department, Thorax Center, Erasmus MC (University Medical Center Rotterdam), Rotterdam, The Netherlands. Since April 2013, he holds the position of Professor of Cardiology in the Cardiovascular Science Division of the National Heart and Lung Institute (NHLI) at the Faculty of Medicine, within the Imperial College of Science, Technology and Medicine, London.He is a Fellow of the American College of Cardiology and a Fellow of the European Society of Cardiology and scientific council of the International College of Angiology.In 1996, he received the TCT Career Achievement Award and in 1997 he was awarded the Wenkebach Prize of the Dutch Heart Foundation. In 2000, he was awarded the Gruentzig Award of the European Society of Cardiology. In 2001, he held the Paul Dudley White Lecture at the American Heart Association in the USA. In 2004, he received the Andreas Gruentzig Award of the Swiss Society of Cardiology. In 2005, he held the 4th International Lecture at the AHA and Mikamo Lecture at the Japanese heart Association. In 2006, he received the highest award of the Clinical Council of the American Heart Association: the James Herrick Award. In 2007, he received the Arrigo Recordati International Prize (Italy) and the ICI Achievement Award (bestowed by the President of Israel – Shimon Perez). In 2008, he received the Einthoven Penning (Leiden). In 2009, he became Doctor Honoris Causa from the University of Athens. In 2011, he received the Lifetime Achievement Award, bestowed by the American College of Cardiology, in recognition of many years of service and invaluable contributions to the ACC. At the end of 2011, Prof Serruys received the Ray C. Fish Award, bestowed by the Texas Heart Institute, for outstanding achievement and contribution to cardiovascular medicine. In 2012, he received a Golden Medal of the European Society of Cardiology. In 2013, he became Doctor Honoris Causa from the Complutense University of Madrid. In 2016, he became Doctor Honoris Causa of the Melbourne University, Australia. Currently he is established Professor of Interventional Medicine and Innovation at the National University of Ireland, Galway.

A consultant cardiologist at Hammersmith Hospital, Imperial College London, UK. Features in 1 video on Wondr Medical. Raffi Kaprielian generally speaks on Instantaneous wave-Free Ratio (iFR), Live Cases, and Coronary Physiology.

Professor Rajesh Kharbanda is a Consultant Cardiologist Oxford University Hospitals, UK with over 20 years of experience in treating patients with a wide range of heart conditions including angina, valve disease, heart failure and irregular heart rhythm. He has special expertise in the treatment of coronary artery disease by coronary angioplasty and stenting including complex angioplasty techniques as well as Structural Heart interventions. He has published and co-authored over 240 scientific papers in peer-reviewed journals and actively involved in international trials evaluating various coronary and transcatheter valve technologies.

Dr Rasha Al-Lamee is an Interventional Cardiology Consultant at Imperial College Healthcare NHS Trust in London, UK. Dr Al-Lamee’s research interests are complex coronary intervention, coronary physiology and invasive intravascular assessment. She designed, conducted and led the ORBITA trial and is the lead author of the primary publication in The Lancet. At Imperial College, she is actively involved in the development and recruitment for a number of multi-centre clinical trials. Dr Al- Lamee has over 40 peer-reviewed publications and has presented at international Cardiology conferences worldwide throughout her clinical career. She studied at the University of Oxford and University College London. She went onto complete her training as a junior doctor on the Barts and the London Medical rotation before being appointed as a Specialist Registrar on the North West London Cardiology rotation in 2006. Dr Al-Lamee has twelve years of Cardiology experience and completed three years of Interventional Fellowship training at Hammersmith Hospital in London. She also spent a year training as an Interventional Fellow under the supervision of Professor Antonio Colombo in Milan. She completed specialist training in Cardiology in 2013.

Dr Ricardo Petraco is a NIHR Lecturer in interventional Cardiology at Imperial College London, performing his clinical work at Hammersmith Hospital. He has been working with coronary physiology at Imperial since 2010 on the development of the novel instantaneous wave-Free Ratio (iFR). Dr Petraco’s work with iFR has led to the proposition of the Hybrid iFR-FFR approach and has established iFR’s close relationship with coronary flow reserve (CFR). His interests in computer programming has led to the development of a software for automated analysis of coronary haemodynamics signals which is been used by many leading centres in the world. He has also pioneered the algorithm for iFR calculation without the need for an ECG signal, an approach which is now implemented in clinical consoles. He has secured several research grants and published extensively in the field of coronary physiology. His current research interests are on the development of methodologies to assess stenosis severity in situations of haemodynamic instability and on the understanding of how medical therapies modulate coronary resistance and flow. Clinically, his interests also include the use of intravascular imaging modalities to optimise PCI and has been engaged in IVUS training for cathlab staff and cardiology trainees.

A consultant/attending. Features in 94 videos on Wondr Medical. SAYAN SEN generally speaks on Fractional Flow Reserve (FFR), Live Cases, Instantaneous wave-Free Ratio (iFR), Renal Denervation (RDN), and Catheter laboratory skills.

Dr Sukhjinder Nijjer is a Consultant Cardiologist and Honorary Senior Clinical Lecturer at Imperial College London. He is the President of Cardiology at the Royal Society of Medicine and is the Communication Lead for the British Cardiovascular Intervention Society. He works at the Hammersmith Hospital as an Interventional Cardiologist and is an expert in Coronary Physiology. His PhD research focused on the development of instantaneous wave-free ratio (iFR) pullback and co-registration. He has published over 100 original academic papers and has involved in the DEFINE-FLAIR, SYNTAX-II and ORBITA-1 and ORBITA-2 research studies.

A medical doctor at Wakayama Medical University, Wakayama, Japan. Features in 16 videos on Wondr Medical. Takashi Akasaka generally speaks on Instantaneous wave-Free Ratio (iFR), Fractional Flow Reserve (FFR), Coronary Flow Reserve (CFR), Coronary Physiology, and Coronary Optical Coherence Tomography (OCT).

Tim van de Hoef, MD, PhD, FESC, is an interventional cardiology fellow at the Amsterdam UMC - VU Medical Center (Amsterdam, The Netherlands). He has been involved in intracoronary physiology research since 2010, and his research has covered the wide spectrum of intracoronary physiology assessed by means of invasive coronary pressure and flow measurements, ranging from functional stenosis severity appraisal to assessment of microvascular function in both stable coronary artery disease and acute coronary syndromes. He obtained a PhD (Cum Laude) in invasive coronary physiology in 2015. He has (co-)authored over 90 papers on the topic of coronary physiology, and his recent research has focused on the use of basal conditions for the assessment of epicardial stenosis severity, and the combined assessment of epicardial and microvascular disease to optimize diagnosis and risk-stratification in ischemic heart disease.

An interventional cardiology at Hammersmith Hospital, Imperial College London, UK. Features in 8 videos on Wondr Medical. Yousif Ahmad generally speaks on Catheter laboratory skills, Drug Eluting Stents (DES), Guidelines, Coronary Artery Bypass Grafting (CABG), and Anti Anginal.

Dr Yuetsu Kikuta is a Senior Consultant Cardiologist, Division of Cardiology, Fukuyama Cardiovascular Hospital, Japan. He studied physiology as a Clinical Research Fellow (2015-2017) and a Faculty, Advances in Coronary Physiology under Dr Justin E Davies, MBBS, PhD, Imperial College London who invented iFR. He was the first author of the first-in-men international online iFR pullback GRADIENT registry (JACC CV Intv 2018). He was a co-author and an investigator of the DEFINE FLAIR study which showed noninferiority of iFR to FFR (NEJM 2017). He has written the protocol of and started the first-in-men randomized control trial of iFR-coregistration-guided revascularization compared to FFR-pullback guidance in patients with stable coronary artery disease with Prof. Hitoshi Matsuo at Gifu Heart Centre as PI since 2020. He has served as a core committee member of Japanese national PCI registry since 2018. His early mentor was Dr Hideo Tamai who developed the first human biodegradable coronary stent system (Igaki Tamai stent, Circulation 2000). He graduated from Kyoto University in 2002.